| dc.description.abstract |
Rotaviruses represent important causes of severe diarrhoea in early childhood. We examined the effect of HIV infection on' the presentation and outcome of rotavirus gastroenteritis in Malawian children. Children younger than 5 years who were treated for acute gastroenteritis at the Queen Elizabeth Central Hospital in Blantyre from July, 1997, to June, 1999, were enrolled Children with rotavirus diarrhoea, with and without HIV infection, were followed up for up to 4 weeks after hospital discharge. Rotavirus disease severity (assessed with a 20-point score), duration of rotavirus shedding, and sero response to rotavirus were compared between HIV-infected and HIV-uninfected children. 736 inpatients (median age 8 months, 271 [34%1 of whom wen; HIV-l.-infected) and 400 outpatients (median age 9 months, 65 [16%] of whom were HIV-infected) were enrolled. Rotavirus was detected less frequently among HIV-infected children (102 of 336 [30%]) than among HIV-uninfected children (348 of 850 [41%], (relative risk 0.71 [95% 01 Cl 0.53-0.87], p=0.0007), There were no differences in rotavirus disease severity for hospitalised children with and without HIV infection, but HIV-infected children were more likely to die during follow-up (11/50 [22%]) than HIV-uninfected children (u/61, p<0-0001). Of 29 HIV-infected and 45 HIV-uninfected children who completed follow-up, six (21%) HIV-infected children shed rotavirus, compared with two (4%) HIV-uninfected children (4-66 [1-01-21-51], p=0-05), but shedding was not associated with diarrhoea. Three-quarters of children exhibited a four-fold rise of serum IgG or lgA to rotavirus, which did not vary by HIV status. Malawian children with concomitant HIV infection resolved acute rotavirus infections. Rotavirus vaccine safety and immunogenicity in HIV-infected infants should now be determined. |
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